People

Michael Carroll

Professor of Pediatrics, Harvard Medical School 

PCMM, Boston Children’s Hospital 

Co-director, MMSc in Immunology, Harvard Medical School 

Email: Michael.carroll@childrens.harvard.edu 

Dr.  Michael Carroll received his Ph.D. in Immunology from the UT Southwestern Medical School (Dallas, TX) under the direction of Dr. J. Donald Capra; subsequently, he trained with Dr. Rodney R. Porter in the Biochemistry Department, Oxford U (Oxford UK). In 1985, he was appointed an Assistant Professor in Pediatrics and the Department of Biological Chemistry at the Children’s Hospital/Harvard Medical School. He was promoted in 1998 to the rank of Professor of Pediatrics, Harvard Medical School and Senior Investigator, Boston Children’s Hospital, Program in Cellular and Molecular Medicine.

Dr. Carroll served as Director of the Harvard Graduate Program in Immunology from 2005 – 2016.  Early in his career, he was an American Arthritis Foundation Fellow and Investigator and later a recipient of a Pew Scholar award. He is a recipient of the 2016 Research Award by National Alliance for Mental Health.

A major focus of his research is understanding how autoreactive germinal centers are regulated; and how peripheral autoimmunity can affect neuropsychiatric behavior.  Moreover, his research includes understanding how changes in the regulation of the complement system in the brain can underlie diseases such as schizophrenia.

Elisabeth Carroll 

DPharm University Paul Sabatier Toulouse, France 

Administrative assistant  

Lab manager 

Email: Elisabeth.carroll@childrens.harvard.edu 

Postdoctoral Fellows

Yingying Zhang 

PhD in Molecular and Cellular Biology, Harvard University 

Email: yingying.zhang@childrens.harvard.edu   

By applying a newly developed technology called MERFISH (Multiplexed Error Robust Fluorescent in-situ Hybridization), I am interested in addressing the following questions: 1) which brain cell types express complement components? 2) where in the brain and when during development are they expressed? 3) how does C4 deficiency or C4 overexpression affect the transcriptional landscape in the mouse brain? The ultimate goal is to understand the role of C4 and the complement pathway during brain development and how mechanistically C4 overexpression can contribute to schizophrenia   

Carlos Castrillon 

PhD in Life Sciences from Universite Paris Diderot, France

Email: carlos.castrillon@childrens.harvard.edu   

During the immune and autoimmune responses, B cells in the germinal center undergo clonal expansion, mutation and selection by interacting with stromal cells and T cells. Germinal center B cells are selected by their capacity to bind foreign or self-antigens.

I’m interested in studying how much of the diversity of germinal center B cells translates into effective memory B cells and antibody-secreting plasma cells.

Esra Yalcin 

PhD in Neuroscience from Istanbul Medipol University 

Email: esra.yalcin@childrens.harvard.edu 

My project is focused on understanding the effect of C4A copy number variation on schizophrenia development by correlating genetic analysis and synapse density analysis in a C4A humanized mouse model and postmortem brain tissue. 

Ajitanuj Rattan

PhD

Email:ajitanuj.rattan@childrens.harvard.edu 

Generation of autoantibodies by auto reactive B cells is one of the major hallmarks of autoimmunity. Apoptotic cells are major source of autoantigens and inefficient clearance of apoptotic cells is central to activation of auto reactive B cells. I am interested in understanding the role of a newly identified complement receptor, NRP1 (CD304) in apoptotic cell clearance (immune complexes) and its implication in regulation of autoimmunity.​​

Siti Rahmayanti

MD Universitas Gadjah Mada, Yogyakarta, Indonesia

 Email: siti.rahmayanti@childrens.harvard.edu 

My project explores B cell primary immune responses within autoimmune environment through characterization of their intrafollicular (germinal center) vs. extrafollicular (plasma cells) compartments.

Graduate students 

Yi Dan (Danni) Zhu

PhD student in Virology. Harvard University 

Email: yidan.zhu@childrens.harvard.edu 

I am interested in understanding the mechanisms behind persistent autoantibody production in SLE and how innate immune sensors regulate autoreactive memory B cell activity. 

Chongyang Wu

Master Student, Immunology, Harvard University

Email: chongyang.wu@childrens.harvard.edu 

My project is to elucidate the role of Complement C3 in brain development and complement regulation using multiplexed error-robust fluorescence in situ hybridization (MERFISH).

Elliot Akama-Garren

MD/PhD student in Immunology. Harvard University

Email: Elliot.akama-garrenl@childrens.harvard.edu 

I’m interested in understanding how interactions between T cells and auto reactive B cells alter the balance between tolerance and autoimmunity.

Ernest Aw  

PhD student in Immunology. Harvard University 

Email: ernest.aw@childrens.harvard.edu   

I am interested in interferon-α (IFNα) dependent modulation of the central nervous system (CNS) and its resulting effects on behavioural phenotypes.

Technicians 

Minghe Ma 

Research technician 

Email: minghe.ma@childrens.harvard.edu   

Melis Yilmaz

Research Technician

Email: melis.yilmaz@childrens.harvard.edu 

Diana Pascual

Animal Technician

Email:diana.pascual@childrens.harvard.edu 

Former Lab Members

 

 

Ming Zhang PhD

Rob Barrington PhD

Ama Agyemang MD/PhD

Isaac Chu PhD                                                                                             

Matt Woodruff PhD

Young-A Kim PhD

Michael Kulinoski PhD

Lisa Pitcher PhD

Santiago Gonzalez PhD

Melissa Turman PhD

Prya Chatterjee PhD

Kaysa Prokopec PhD

Caroline Herndon PhD

Blandine Mercier  PhD

Nishant Dwivedi PhD

Joseph O’Flynn PhD

Esteban Fernandez PhD

Jessica Perego PhD

Balthasar Heesters PhD

Fahd Al Quresha 

Dan Firl MD 

Soren Degn PhD

Abhishek Das PhD

Jonatan Chang PhD

Jessy Presumey PhD

Cees van der Poel PhD

Lea Simoni PhD

Theo van den Broeck  MD/PhD